Marvel Studios has already confirmed that Sam Wilson, now Captain America in the MCU, will take on several different villains in 2025’s upcoming Captain America: Brave New World.

Anthony Mackie’s Sam Wilson officially became Captain America at the end of 2021’s The Falcon and the Winter Soldier, but Brave New World will mark his theatrical debut as the Star-Spangled Man. Following in Steve Rogers’ footsteps is a tall order, so Marvel Studios’ Captain America: Brave New World needs to make a strong impression, and it’s doing this through its villains.

While most superheroes in the MCU take on perhaps one or two villains in their solo movies, Sam Wilson’s Captain America is set to take on a plethora of brilliant antagonists in his first headliner movie. Trailers for Captain America: Brave New World and set photos from the production of the Phase 5 movie have, so far, confirmed five powerful villains making their debuts or returns to the MCU. These villains will surely create a huge web of problems for Sam Wilson’s Captain America, but could set up some thrilling new stories for the MCU’s future.